(R)-(+)-Bay-K-8644

Research use only, not for human use.

(R)-(+)-Bay-K-8644 is a Ca2+ channel and dihydropyridine agonist that inhibits Ba2+ currents (IBa), induces central respiratory depression in cats, and inhibits platelet activation through competitive antagonism of thromboxane A2-prostaglandin H2 receptors.

(R)-(+)-Bay-K-8644 is a calcium channel inhibitor. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM).

(R)-(+)-Bay-K-8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist.Each optical isomer possesses opposite effects on IBa, (R)-(+)-Bay-K-8644 as an antagonist and S(-)-Bay K 8644 as an agonist. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM). When (R)-(+)-Bay-K-8644 (0.5 μM) is applied, IBa is suppressed to 71±10% of control.In the presence of (R)-(+)-Bay-K-8644IBa. (R)-(+)-Bay-K-8644 is a calcium channel inhibitor.

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Metabolic Enzyme/Protease

PPAR

PPAR | Calcium Channel

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98791-67-4

356.3

C16H15F3N2O4

>98% (HPLC)

In Vitro:?DMSO : ≥ 300 mg/mL (841.99 mM)

COC(=O)C1=C(C)NC(C)=C([C@@H]1c1ccccc1C(F)(F)F)[N+]([O-])=O

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(-20℃)

With Ice Pack

≥ 2 years