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5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole
5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole
CAS No. 2863687-18-5
5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole( —— )
Catalog No. M37686 CAS No. 2863687-18-5
Antileishmanial agent-2 is a 3-Br-isoxazoline-Based Inhibitors against Plasmodium falciparum (D10 and W2 strains) and Leishmania spp. (L. infantum and L. tropica) Promastigotes with IC50s of 0.035, 0.058, 3.5 and 7.5 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 155 | In Stock |
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| 5MG | 149 | In Stock |
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| 10MG | 220 | In Stock |
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| 25MG | 337 | In Stock |
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| 50MG | 462 | In Stock |
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| 100MG | 619 | In Stock |
|
| 200MG | 835 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole
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NoteResearch use only, not for human use.
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Brief DescriptionAntileishmanial agent-2 is a 3-Br-isoxazoline-Based Inhibitors against Plasmodium falciparum (D10 and W2 strains) and Leishmania spp. (L. infantum and L. tropica) Promastigotes with IC50s of 0.035, 0.058, 3.5 and 7.5 μM.
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DescriptionAntileishmanial agent-2 shows submicromolar antileishmanial activity (IC50 = 0.29 μM) and a very high selectivity index with respect to mammalian cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMicrobiology/Virology
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TargetParasite
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RecptorParasite
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Research Area——
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Indication——
Chemical Information
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CAS Number2863687-18-5
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Formula Weight350.21
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Molecular FormulaC15H16BrN3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESC(C)(C)(C)C1=CC=C(C=2N=C(ON2)C3ONC(Br)=C3)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Galbiati A, et al. Development of Potent 3-Br-isoxazoline-Based Antimalarial and Antileishmanial Compounds. ACS Med Chem Lett. 2021 Oct 13;12(11):1726-1732. ?
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