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Tafenoquine

CAS No. 106635-80-7

Tafenoquine( SB-252263 | Tafenoquine | WR 238605 )

Catalog No. M10284 CAS No. 106635-80-7

Tafenoquine (SB-252263, Tafenoquine, WR 238605) is a long-acting, orally active anti-malarial agent to prevent malaria that is holoendemic for Plasmodium falciparum.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Tafenoquine
  • Note
    Research use only, not for human use.
  • Brief Description
    Tafenoquine (SB-252263, Tafenoquine, WR 238605) is a long-acting, orally active anti-malarial agent to prevent malaria that is holoendemic for Plasmodium falciparum.
  • Description
    Tafenoquine (SB-252263, Tafenoquine, WR 238605) is a long-acting, orally active anti-malarial agent to prevent malaria that is holoendemic for Plasmodium falciparum.Parasite Infection Phase 3 Clinical(In Vitro):Tafenoquine exhibits no anti-malarial activity in CYP 2D knock-out mice when dosed at their ED100 values (3 mg/kg) established in WT mice. Tafenoquine anti-malarial activity is partially restored in humanized/CYP 2D6 knock-in mice when tested at two times its ED100 (6 mg/kg).
  • In Vitro
    ——
  • In Vivo
    Tafenoquine exhibits no anti-malarial activity in CYP 2D knock-out mice when dosed at their ED100 values (3 mg/kg) established in WT mice. Tafenoquine anti-malarial activity is partially restored in humanized/CYP 2D6 knock-in mice when tested at two times its ED100 (6 mg/kg).
  • Synonyms
    SB-252263 | Tafenoquine | WR 238605
  • Pathway
    Microbiology/Virology
  • Target
    Parasite
  • Recptor
    Parasite
  • Research Area
    Infection
  • Indication
    Parasite Infection

Chemical Information

  • CAS Number
    106635-80-7
  • Formula Weight
    463.501
  • Molecular Formula
    C24H28F3N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=CC(=NC2=C1C(=C(C=C2NC(C)CCCN)OC)OC3=CC=CC(=C3)C(F)(F)F)OC
  • Chemical Name
    N4-(2,6-dimethoxy-4-methyl-5-(3-(trifluoromethyl)phenoxy)quinolin-8-yl)pentane-1,4-diamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shanks GD, et al. Clin Infect Dis. 2001 Dec 15;33(12):1968-74. 2. Ramharter M, et al. Am J Trop Med Hyg. 2002 Jul;67(1):39-43. 3. Pradines B, et al. Antimicrob Agents Chemother. 2006 Sep;50(9):3225-6.
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