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MAO-B-IN-5
CAS No. 849909-77-9
MAO-B-IN-5( —— )
Catalog No. M37657 CAS No. 849909-77-9
MAO-B-IN-5 is a potent, selective, and orally active MAO-B inhibitor with an IC50 of 0.204 μM, showing potential for research in Parkinson's disease (PD) .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 236 | Get Quote |
|
| 5MG | 366 | Get Quote |
|
| 10MG | 521 | Get Quote |
|
| 25MG | 756 | Get Quote |
|
| 50MG | 1021 | Get Quote |
|
| 100MG | 1350 | Get Quote |
|
| 200MG | 1764 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMAO-B-IN-5
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NoteResearch use only, not for human use.
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Brief DescriptionMAO-B-IN-5 is a potent, selective, and orally active MAO-B inhibitor with an IC50 of 0.204 μM, showing potential for research in Parkinson's disease (PD) .
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DescriptionMAO-B-IN-5 is a potent, selective and orally active MAO-B inhibitor with an IC50 of 0.204 μM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD).
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In VitroMAO-B-IN-5 (compound D0) (Sf9 cells) shows inhibitory activities towards MAO with the IC50s of 34.190 μM and 0.204 μM for MAO-A and MAO-B, respectively.
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In VivoMAO-B-IN-5 (1 mg/kg, i.v.; 5 mg/kg, p.o.) shows oral bioavailability in rats (F=13.6%).Pharmacokinetic Parameters of MAO-B-IN-5 in SD rats.SD rats; 1 mg/kg, i.v.; 5 mg/kg, p.o..Animal Model:SD rats Dosage:1, 5 mg/kg Administration:1 mg/kg, i.v.; 5 mg/kg, p.o.Result:Showed oral bioavailability in rats (F=16.3%).
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number849909-77-9
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Formula Weight328.38
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Molecular FormulaC19H21FN2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESC(N1[C@H](C(N)=O)CCC1)C2=CC=C(OCC3=CC(F)=CC=C3)C=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang Z,et al. Enhancing monoamine oxidase B inhibitory activity via chiral fluorination: Structure-activity relationship, biological evaluation, and molecular docking study. Eur J Med Chem. 2022; 228:114025.?
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