MAO-B-IN-5

CAS No. 849909-77-9

MAO-B-IN-5( —— )

Catalog No. M37657 CAS No. 849909-77-9

MAO-B-IN-5 is a potent, selective, and orally active MAO-B inhibitor with an IC50 of 0.204 μM, showing potential for research in Parkinson's disease (PD) .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 366 In Stock
10MG 521 In Stock
25MG 781 In Stock
50MG 1032 In Stock
100MG 1395 In Stock
200MG 1823 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    MAO-B-IN-5
  • Note
    Research use only, not for human use.
  • Brief Description
    MAO-B-IN-5 is a potent, selective, and orally active MAO-B inhibitor with an IC50 of 0.204 μM, showing potential for research in Parkinson's disease (PD) .
  • Description
    MAO-B-IN-5 is a potent, selective and orally active MAO-B inhibitor with an IC50 of 0.204 μM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD).
  • In Vitro
    MAO-B-IN-5 (compound D0) (Sf9 cells) shows inhibitory activities towards MAO with the IC50s of 34.190 μM and 0.204 μM for MAO-A and MAO-B, respectively.
  • In Vivo
    MAO-B-IN-5 (1 mg/kg, i.v.; 5 mg/kg, p.o.) shows oral bioavailability in rats (F=13.6%).Pharmacokinetic Parameters of MAO-B-IN-5 in SD rats.SD rats; 1 mg/kg, i.v.; 5 mg/kg, p.o..Animal Model:SD rats Dosage:1, 5 mg/kg Administration:1 mg/kg, i.v.; 5 mg/kg, p.o.Result:Showed oral bioavailability in rats (F=16.3%).
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    849909-77-9
  • Formula Weight
    328.38
  • Molecular Formula
    C19H21FN2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(N1[C@H](C(N)=O)CCC1)C2=CC=C(OCC3=CC(F)=CC=C3)C=C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang Z,et al. Enhancing monoamine oxidase B inhibitory activity via chiral fluorination: Structure-activity relationship, biological evaluation, and molecular docking study. Eur J Med Chem. 2022; 228:114025.?
molnova catalog
related products
  • 8-Hydroxygenistein

    8-Hydroxygenistein (8-OHG) is an antioxidant that can effectively scavenge nitric oxide (NO) and superoxide anion (O??). 8-Hydroxygenistein belongs to ortho-dihydroxy isoflavones (ODI) and is abundantly present in dark soy sauce and light soy sauce. Its antioxidant activity is stronger than that of its parent compound genistein. The content of 8-Hydroxygenistein is positively correlated with the antioxidant capacity of soy sauce (r = 0.959), and it remains highly stable even after being heated in boiling water for 60 minutes. During the brewing and storage of soy sauce, 8-Hydroxygenistein effectively prevents oxidative damage, making it promising for use in food antioxidant research.

  • N-3-Oxo-octanoyl-L-h...

    N-3-Oxo-octanoyl-L-homoserine lactone, a quorum-sensing signal, is an Agrobacterium autoinducer.

  • Bovine albumin

    Bovine albumin is a?globular protein that is used in numerous biochemical applications.