Pim-1/2 kinase inhibitor 1

Research use only, not for human use.

Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides.

Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and p27Kip1. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer.

Pim-1/2 kinase inhibitor 1 (compound D14) (varying concentrations; 48 h) shows cytotoxicity to PC3 cells, with an IC of 11 μM.Cell Cytotoxicity Assay Cell Line:PC3 cells Concentration:varying concentrations Incubation Time:48 h Result:Inhibited PC3 cells with an IC of 11 μM.

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JAK/STAT Signaling

Pim

Pim

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6320-51-0

235.26

C11H9NO3S

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (1062.65 mM; Ultrasonic (<60°C)

COc1ccc(C=C2SC(=O)NC2=O)cc1

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(-20℃)

With Ice Pack

≥ 2 years