Cart
sales@molnova.com
HNPMI
CAS No. 1980848-48-3
HNPMI( —— )
Catalog No. M37340 CAS No. 1980848-48-3
HNPMI is an EGFR inhibitor that induces G0/G1 phase arrest of CRC cells in colorectal cancer, regulates enzymes associated with apoptosis, and can promote apoptosis, and can be used for the study of colorectal cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 33 | In Stock |
|
| 5MG | 53 | In Stock |
|
| 10MG | 88 | In Stock |
|
| 25MG | 180 | In Stock |
|
| 50MG | 276 | In Stock |
|
| 100MG | 454 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 986 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameHNPMI
-
NoteResearch use only, not for human use.
-
Brief DescriptionHNPMI is an EGFR inhibitor that induces G0/G1 phase arrest of CRC cells in colorectal cancer, regulates enzymes associated with apoptosis, and can promote apoptosis, and can be used for the study of colorectal cancer.
-
DescriptionHNPMI is an inhibitor of EGFR and has cytotoxic effects on tumor cells. HNPMI can downregulate the protein levels of osteopontin, survivin and cathepsin S, leading to apoptosis. HNPMI also regulates BCL-2/BAX and p53 in CRC cell lines to inhibit tumorigenesis.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorApoptosis | EGFR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1980848-48-3
-
Formula Weight360.41
-
Molecular FormulaC22H20N2O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=[N+]([O-])C1=CC=C(C(C(N2C3=C(CC2)C=CC=C3)C4=CC=C(C)C=C4)=C1)O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kandhavelu J, et al. A novel EGFR inhibitor, HNPMI, regulates apoptosis and oncogenesis by modulating BCL-2/BAX and p53 in colon cancer. Br J Pharmacol. 2024 Jan;181(1):107-124.?
molnova catalog
related products
-
Phenoxodiol
Phenoxodiol activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apoptosis.
-
Exisulind
Exisulind induces apoptosis through the activation of protein kinase G (PKG). Exisulind exhibits antineoplastic activity in solid tumour and haematological cancer cell lines and is an inhibitor of tumour growth in rodent models of colon, prostate, bladder, mammary and lung cancer.
-
NSC 745887
NSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage.
