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YS-67
CAS No. 2761327-15-3
YS-67( —— )
Catalog No. M37328 CAS No. 2761327-15-3
YS-67 is an orally available, selective and potent EGFR inhibitor with antitumor activity, inhibits p-EGFR and p-AKT, and inhibits the proliferation of A549, PC-9, and A431 cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 56 | Get Quote |
|
| 5MG | 82 | Get Quote |
|
| 10MG | 135 | Get Quote |
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| 25MG | 272 | Get Quote |
|
| 50MG | 451 | Get Quote |
|
| 100MG | 745 | Get Quote |
|
| 500MG | 1485 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameYS-67
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NoteResearch use only, not for human use.
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Brief DescriptionYS-67 is an orally available, selective and potent EGFR inhibitor with antitumor activity, inhibits p-EGFR and p-AKT, and inhibits the proliferation of A549, PC-9, and A431 cells.
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DescriptionYS-67 is a potent inhibitor of EGFR with an IC 50 of 5.2 nM. YS-67 significantly inhibits p-EGFR and p-AKT. YS-67 inhibits the proliferation of A549, PC-9, and A431cells with IC 50s of 4.1, 0.5, and 2.1 μM, respectively.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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RecptorAkt | EGFR | Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number2761327-15-3
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Formula Weight522.64
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Molecular FormulaC32H34N4O3
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Purity>98% (HPLC)
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Solubility——
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SMILESN=1C=NC(=C2C=C(OCCCN3CCOCC3)C(OC)=CC12)C=4C=5C=CC=CC5N(C4C=6C=CC=CC6)CC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. He P, et al. Design, synthesis and biological evaluation of structurally new 4-indolyl quinazoline derivatives as highly potent, selective and orally bioavailable EGFR inhibitors. Bioorg Chem. 2024 Jan;142:106970.?
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