Cart
sales@molnova.com
VGSCs-IN-1
CAS No. 1204296-79-6
VGSCs-IN-1( —— )
Catalog No. M37270 CAS No. 1204296-79-6
VGSCs-IN-1 is a potent VGSC inhibitor, a 2-piperazine analog of Riluzole that exhibits good blocking activity on Nav1.4.VGSCs-IN-1 can be used to study cellular excitability disorders.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 321 | In Stock |
|
| 10MG | 459 | In Stock |
|
| 25MG | 718 | In Stock |
|
| 50MG | 958 | In Stock |
|
| 100MG | 1274 | In Stock |
|
| 200MG | 1721 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameVGSCs-IN-1
-
NoteResearch use only, not for human use.
-
Brief DescriptionVGSCs-IN-1 is a potent VGSC inhibitor, a 2-piperazine analog of Riluzole that exhibits good blocking activity on Nav1.4.VGSCs-IN-1 can be used to study cellular excitability disorders.
-
DescriptionVGSCs-IN-1 (compound 14), a 2-piperazine analog of Riluzole (HY-B0211), is a human voltage-gated sodium channels (VGSCs) inhibitor. VGSCs-IN-1 shows great Nav1.4 blocking activity. VGSCs-IN-1 has a pKa of 7.6 and a cLog P of 2.4. VGSCs-IN-1 can be used for cell excitability disorders research.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayMembrane Transporter/Ion Channel
-
TargetSodium Channel
-
RecptorSodium Channel
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1204296-79-6
-
Formula Weight303.3
-
Molecular FormulaC12H12F3N3OS
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESFC(F)(F)OC1=CC2=C(C=C1)N=C(S2)N1CCNCC1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Farinato A, et al. Development of Riluzole Analogs with Improved Use-Dependent Inhibition of Skeletal Muscle Sodium Channels. ACS Med Chem Lett. 2023 Jun 23;14(7):999-1008.?
molnova catalog
related products
-
QX-314 chloride
QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.
-
APETx2
Acid-sensing ion channel 3 (ASIC3) channel blocker (IC50 values are 63 and 175 nM for homomeric rat and human ASIC3 channels). Also inhibits NaV1.8 and NaV1.2 channels (IC50 values are 55 and 114 nM respectively). Demonstrates analgesic properties against acid-induced and inflammatory pain.
-
Pilsicainide HCl
Pilsicainide HCl is a pure sodium channel blocker.
