TWIK-1/TREK-1-IN-3

Research use only, not for human use.

TWIK-1/TREK-1-IN-3 is a selective and potent inhibitor of the potassium channel TREK-1, effectively inhibiting TREK-1 homodimers and TWIK-1/TREK-1 heterodimers containing two-pore-domain potassium (K2p) channels.

TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.74 μM and 16.5 μM, respectively, and has antidepressant-like effects.

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Cell Cycle/DNA Damage

Potassium Channel

Potassium Channel

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1440532-33-1

372.43

C19H27F3N2O2

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (67.13 mM; Ultrasonic (<60°C)

C([C@@H](COC1=CC=C(C(F)(F)F)C=C1)O)N2CCC(CC2)N3CCCC3

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(-20℃)

With Ice Pack

≥ 2 years