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TWIK-1/TREK-1-IN-3
CAS No. 1440532-33-1
TWIK-1/TREK-1-IN-3( —— )
Catalog No. M37218 CAS No. 1440532-33-1
TWIK-1/TREK-1-IN-3 is a selective and potent inhibitor of the potassium channel TREK-1, effectively inhibiting TREK-1 homodimers and TWIK-1/TREK-1 heterodimers containing two-pore-domain potassium (K2p) channels.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 122 | Get Quote |
|
| 5MG | 188 | Get Quote |
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| 10MG | 312 | Get Quote |
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| 25MG | 504 | Get Quote |
|
| 50MG | 720 | Get Quote |
|
| 100MG | 954 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTWIK-1/TREK-1-IN-3
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NoteResearch use only, not for human use.
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Brief DescriptionTWIK-1/TREK-1-IN-3 is a selective and potent inhibitor of the potassium channel TREK-1, effectively inhibiting TREK-1 homodimers and TWIK-1/TREK-1 heterodimers containing two-pore-domain potassium (K2p) channels.
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DescriptionTWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.74 μM and 16.5 μM, respectively, and has antidepressant-like effects.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorPotassium Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number1440532-33-1
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Formula Weight372.43
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Molecular FormulaC19H27F3N2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (67.13 mM; Ultrasonic (<60°C)
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SMILESC([C@@H](COC1=CC=C(C(F)(F)F)C=C1)O)N2CCC(CC2)N3CCCC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lee EH, et al. Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants. Biomed Pharmacother. 2023 Sep;165:115139.. .?
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