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BMS-191011
CAS No. 202821-81-6
BMS-191011( BMS-A )
Catalog No. M20837 CAS No. 202821-81-6
BMS-191011 is an activator of large-conductance calcium-activated potassium (BKCa) channels effective in stroke models.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 55 | In Stock |
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| 2MG | 32 | In Stock |
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| 5MG | 48 | In Stock |
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| 10MG | 75 | In Stock |
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| 25MG | 155 | In Stock |
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| 50MG | 286 | In Stock |
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| 100MG | 431 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBMS-191011
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NoteResearch use only, not for human use.
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Brief DescriptionBMS-191011 is an activator of large-conductance calcium-activated potassium (BKCa) channels effective in stroke models.
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DescriptionBMS-191011 is an activator of large-conductance calcium-activated potassium (BKCa) channels effective in stroke models.
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In VitroBMS-191011 (20 or 40 μM) activates BK channels in IGR39 cells, and leads to potentiation in Panc-1 cells. Cell Viability Assay Cell Line:IGR39 and Panc-1 cells Concentration:20 or 40 μM Incubation Time:Result:Activated BK channels in less than 50% IGR39 cells and led to less than two-fold potentiation in Panc-1 cells.Promoted the activation of a voltage-independent K+ conductance at negative voltages.
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In VivoBMS-191011 (intravenous injection; 10-100 μg/kg; once) dilates rat retinal arterioles through activation of iberiotoxin-sensitive BK(Ca) channels in vivo. Animal Model:Male Wistar rats (8- to 10-week-old) treated with Tetrodotoxin (50 μg/kg, intravenously (i.v.)) Dosage:10-100 μg/kg Administration:Intravenous injection; 10-100 μg/kg; once Result:Increased the diameter of retinal arterioles, showed no significant effect on mean arterial pressure and heart rate.
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SynonymsBMS-A
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorPotassium Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number202821-81-6
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Formula Weight370.71
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Molecular FormulaC16H10ClF3N2O3
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (337.19 mM)
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SMILESO=c1oc(-c2ccc(C(F)(F)F)cc2)nn1Cc1cc(Cl)ccc1O
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Chemical Name134-Oxadiazol-2(3H)-one 3-((5-chloro-2-hydroxyphenyl)methyl)-5-(4-(trifluoromethyl)phenyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Mori A Suzuki S Sakamoto K et al. BMS-191011 an Opener of Large-Conductance Ca2+-Activated Potassium Channels Dilates Rat Retinal Arterioles in Vivo[J]. Biological & Pharmaceutical Bulletin 2011 34(1):150-152.
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