Sodium zirconium cyclosilicate( —— )

Catalog No. M37191 CAS No. 17141-74-1

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Product Name

Sodium zirconium cyclosilicate
Note

Research use only, not for human use.
Brief Description

Sodium zirconium cyclosilicate (UXSi-9) is a novel selective cation exchanger and a K+ binder that can be used to remove excess K+ from the body and can be used in the treatment of hyperkalemia.
Description

Sodium zirconium cyclosilicate is an orally administered, non-absorbed, novel, inorganic microporous zirconium silicate compound, is a highly selective cation exchanger that selectively removes excess K+ in vivo. Sodium zirconium cyclosilicate can be used in research of chronic kidney disease (CKD).
In Vitro

Sodium zirconium cyclosilicate (ZS-9) is an inorganic cation exchange crystalline compound that has a high capacity to selectively entrap monovalent cations, specifically excess K+ and ammonium ions. Sodium zirconium cyclosilicatehas the exchange capacities for the divalent ions Ca2+ and Mg2+ are below 0.05 mEq/g, and a >25-fold selectivity for K+ over either Ca2+ or Mg2+.
In Vivo

Sodium zirconium cyclosilicate (ZS-9; 2-6 g/kg; p.o.; daily, for 5 d) is a recovery in feces of Sprague-Dawley rats and can efficient uptake and removal of potassium ions.Animal Model:Sprague-Dawley rats Dosage:2, 4, and 6 g/kg Administration:Oral administration; daily, for 5 days Result:Had 99% fecal recovery in rats.Uptake and removal of potassium ions in a dose-dependent manner.
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Indication

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1. Stavros F, et, al. Characterization of structure and function of ZS-9, a K+ selective ion trap. PLoS One. 2014 Dec 22;9(12):e114686.?

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