β-Aminoarteether

Research use only, not for human use.

β-Aminoarteether (SM934 free base), an orally active derivative of Artemisinin, serves a pivotal role in the research of inflammation and autoimmune disorders, including those related to lupus diseases.

β-Aminoarteether (SM934 free base) is an Artemisinin derivative with orally active. β-Aminoarteether can be used for inflammation and autoimmune disease research, such as lupus diseases.

β-Aminoarteether (SM934;10 μM; 24 hours) treatment directly enhances IL-10 production and suppresses IL-12/23p40 production in primary peritoneal macrophages with IFN-γ stimulation. In vitro, β-Aminoarteether (SM934) could suppress the Th1 and Th17 polarization, but exerted no influence on Treg differentiation.

β-Aminoarteether (SM934; 1-10 mg/kg; oral administration; daliy; for 3 months) treatment significantly delays the progression of glomerulonephritis and increases the survival rate of NZB/W F1 mice. β-Aminoarteether treatment promots the IL-10 production of macrophages from NZB/W F1 mice.Animal Model:Female NZB/W F1 mice (Six and half months old) Dosage:1 mg/kg, 3 mg/kg, and 10 mg/kg Administration:Oral administration; daliy; for 3 months Result:Significantly delayed the progression of glomerulonephritis and increased the survival rate of NZB/W F1 mice.

——

Others

Other Targets

Others

——

——

133162-24-0

327.42

C17H29NO5

>98% (HPLC)

——

C[C@@H]1[C@]2([C@]34[C@@](O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])(O[C@@H]1OCCN)[H])[H]

——

(-20℃)

With Ice Pack

≥ 2 years