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Wu-5
CAS No. 2630378-05-9
Wu-5( —— )
Catalog No. M37111 CAS No. 2630378-05-9
Wu-5 is a potent USP10 inhibitor that inhibits FLT3 and AMPK pathways, promoting the breakdown of FLT3-ITD and inducing apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 150 | In Stock |
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| 10MG | 236 | In Stock |
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| 25MG | 377 | In Stock |
|
| 50MG | 529 | In Stock |
|
| 100MG | 731 | In Stock |
|
| 200MG | 1004 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameWu-5
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NoteResearch use only, not for human use.
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Brief DescriptionWu-5 is a potent USP10 inhibitor that inhibits FLT3 and AMPK pathways, promoting the breakdown of FLT3-ITD and inducing apoptosis.
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DescriptionWu-5 is a USP10 inhibitor that can inhibit FLT3 and AMPK pathways, induce FLT3-ITD degradation and induce apoptosis.
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In VitroCell Viability Assay Cell Line:U937, HL60, MV4-11, Molm13, and MV4-11-R cells Concentration:10 μM Incubation Time:24, 48, 72 h Result:Significantly inhibited the growth of the FLT3-ITD-positive cells (MV4-11, MV4-11-R and Molm13 cells), but had no or little effect on the proliferation of the FLT3-ITD negative cells (U937 and HL60 cells).Apoptosis Analysis Cell Line:MV4-11, and Molm13 cells Concentration:1, 2.5, 5 μM Incubation Time:24, 48 h Result:Induced the apoptosis of MV4-11 and Molm13 in a concentration and time-dependent manner.Western Blot Analysis Cell Line:MV4-11, MV4-11-R, and Molm13 cells Concentration:5 μM Incubation Time:24 h Result:Induced FLT3-ITD degradation.
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorDUB
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Research Area——
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Indication——
Chemical Information
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CAS Number2630378-05-9
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Formula Weight351.33
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Molecular FormulaC15H13NO7S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (71.16 mM; Ultrasonic (<60°C)
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SMILESO=C(C1=CC=C(C=C1)OC2=C([N+]([O-])=O)C=C(C(OCC)=O)S2)OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Miao Yu, et al. Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways. Acta Pharmacol Sin. 2021 Apr;42(4):604-612.??
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