ROS-generating?agent?1( —— )

Catalog No. M37110 CAS No. 2369030-41-9

Ros-generating agent 1 has anticancer activity and generates ROS by covalently modifying Sec-498 residues of TrxR.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

ROS-generating?agent?1
Note

Research use only, not for human use.
Brief Description

Ros-generating agent 1 has anticancer activity and generates ROS by covalently modifying Sec-498 residues of TrxR.
Description

ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Apoptosis
Target

Ferroptosis
Recptor

Ferroptosis | ROS Kinase | Apoptosis
Research Area

——
Indication

——

Chemical Information

CAS Number

2369030-41-9
Formula Weight

411.34
Molecular Formula

C21H15F6NO
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 33.33 mg/mL (81.03 mM; Ultrasonic )
SMILES

C(=C\1/C(=O)\C(=C\C2=CC(C(F)(F)F)=CC=C2)\CNC1)\C3=CC(C(F)(F)F)=CC=C3
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Liu X, et al. Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition. Eur J Med Chem. 2023 Mar 15;250:115191.?

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