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COX-2-IN-34
CAS No. 2788578-71-0
COX-2-IN-34( —— )
Catalog No. M36994 CAS No. 2788578-71-0
COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 278 | In Stock |
|
| 10MG | 413 | In Stock |
|
| 25MG | 642 | In Stock |
|
| 50MG | 863 | In Stock |
|
| 100MG | 1144 | In Stock |
|
| 200MG | 1544 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCOX-2-IN-34
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NoteResearch use only, not for human use.
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Brief DescriptionCOX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice.
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DescriptionCOX-2-IN-34 (compound 8a) is a selective and orally active inhibitor of COX-2 , with an IC50 of 0.42 μM. COX-2-IN-34 has no gastric ulcer toxicity but has anti-inflammatory effects.
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In Vitro——
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In VivoAnimal Model:The Carrageenan-induced rat paw edema assay model Dosage:50 mg/kg Administration:Subcutaneous injection (s.c.)Result:Expressed the reduction of edema claw volume after 0h, 1 h, 2 h, 3h, 4 h, and 6 h of carrageenan injection compared to the control group. Exhibited superior inhibition of 42.90% and 45.95% at the 3rd and 4th hour, respectively, which was comparatively much closer in potency to that of the Celecoxib (HY-14398) group (45.18% inhibition of edema at 3h).
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorCOX
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Research Area——
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Indication——
Chemical Information
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CAS Number2788578-71-0
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Formula Weight245.23
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Molecular FormulaC13H11NO4
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Purity>98% (HPLC)
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Solubility——
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SMILESC(NC1=C(O)C=CC=C1)(=O)C2=C(O)C(O)=CC=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Min Xin, et al. Synthesis and biological evaluation of resveratrol amide derivatives as selective COX-2 inhibitors. Chemico-Biological Interactions. Volume 380, 1 August 2023, 110522.
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