Analgin( Dipyrone | NSC-73205 | NSC 73205 | NSC73205 | Anador | Novalgin )

Catalog No. M15189 CAS No. 5907-38-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Analgin
Note

Research use only, not for human use.
Brief Description

A drug that has analgesic, anti-inflammatory, and antipyretic properties.
Description

A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of aminopyrine. Because of the risk of serious adverse effects its use is justified only in serious situations where no alternative is available or suitable.
In Vitro

Cell Proliferation Assay Cell Line:PaTu 8988 t, Panc-1 Concentration:1, 10, 100, 250, 500 μM Incubation Time:48 h Result:Inhibited proliferation in the PaTu 8988 t cell line with 1–500 μM and with concentrations of 1 μM, 10 μM, 100 μM, and 250 μM in the Panc-1 cell line.
In Vivo

Animal Model:Neuropathic pain rat model Dosage:500 mg/kg Administration:intraperitoneally preemptively at 16 and 1 h before Chronic constriction injury (CCI) and then twice a day for 7 days.Result:Decreased the expression of pronociceptive interleukins (IL-1beta, IL-6, and IL-18) and chemokines (CCL2, CCL4, and CCL7).Animal Model:Pain model in rats Dosage:250 or 500 mg/kg Administration:p.o.Result:Decreased the COX-2 gene expression at 500 mg/kg and increased the MPO gene expression.Reduced MDA levels in the carrageenan paw test and increased tGSH levels.
Synonyms

Dipyrone | NSC-73205 | NSC 73205 | NSC73205 | Anador | Novalgin
Pathway

Chromatin/Epigenetic
Target

COX
Recptor

COX-1
Research Area

Inflammation/Immunology
Indication

——

CAS Number

5907-38-0
Formula Weight

333.34
Molecular Formula

C13H16N3NaO4S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=S(CN(C1=C(C)N(C)N(C2=CC=CC=C2)C1=O)C)([O-])=O.[H]O[H].[Na+]
Chemical Name

sodium ((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)amino)methanesulfonate hydrate