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LEI110
CAS No. 2313525-90-3
LEI110( —— )
Catalog No. M28884 CAS No. 2313525-90-3
LEI110 is a potent Phospholipase A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol hydrolases (i.e., PLA2G16, HRASLS2, RARRES3 and iNAT).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 202 | In Stock |
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| 5MG | 202 | In Stock |
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| 10MG | 297 | In Stock |
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| 25MG | 506 | In Stock |
|
| 50MG | 714 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLEI110
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NoteResearch use only, not for human use.
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Brief DescriptionLEI110 is a potent Phospholipase A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol hydrolases (i.e., PLA2G16, HRASLS2, RARRES3 and iNAT).
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DescriptionLEI110 is a potent Phospholipase A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol hydrolases (i.e., PLA2G16, HRASLS2, RARRES3 and iNAT).(In Vitro):LEI110 reduces cellular arachidonic acid levels in PLA2G16-overexpressing U2OS cells and oleic acid-induced steatosis in human HepG2 cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPhospholipase
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2313525-90-3
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Formula Weight456.46
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Molecular FormulaC25H23F3N2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (219.08 mM)
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SMILESO=C(CCCc1ccccc1)C(NCCc(cc1)ccc1Oc1ncc(C(F)(F)F)cc1)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lv T, et, al. The chemical constituents from the roots of Gentiana crassicaulis and their inhibitory effects on inflammatory mediators NO and TNF-α. Natural Products and Bioprospecting. 2012 Sep 18. (2): 217-221.
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