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Carboxylesterase-IN-2
CAS No. 2764748-88-9
Carboxylesterase-IN-2( —— )
Catalog No. M36936 CAS No. 2764748-88-9
Carboxylesterase-IN-2 is a potent Carboxylesterase Notum inhibitor (IC50 <= 10 nM).Carboxylesterase-IN-2 has potential for the study of cancer diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 150 | In Stock |
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| 5MG | 136 | In Stock |
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| 10MG | 216 | In Stock |
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| 25MG | 370 | In Stock |
|
| 50MG | 498 | In Stock |
|
| 100MG | 686 | In Stock |
|
| 200MG | 923 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCarboxylesterase-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionCarboxylesterase-IN-2 is a potent Carboxylesterase Notum inhibitor (IC50 <= 10 nM).Carboxylesterase-IN-2 has potential for the study of cancer diseases.
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DescriptionCarboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayWnt/Notch/Hedgehog
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TargetWnt/beta/catenin
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RecptorWnt/beta-catenin | Lipid
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Research Area——
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Indication——
Chemical Information
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CAS Number2764748-88-9
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Formula Weight272.33
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Molecular FormulaC13H12N4OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (183.60 mM; Ultrasonic )
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SMILESO=C1N2C(C=CC(SC3=CC(C)=C(C)C=C3)=N2)=NN1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Steadman D, et al. Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J Med Chem. 2022;65(1):562-578.?
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