Cart
sales@molnova.com
Home - Products - Autophagy - CCR - Leronlimab

Leronlimab

CAS No. 674782-26-4

Leronlimab( —— )

Catalog No. M36806 CAS No. 674782-26-4

Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody with both anti-HIV and anti-tumor activity, inhibiting CCR-mediated HIV-1 virus and cancer cell metastasis in mouse tumor models. Leronlimab can be used to study HIV, non-alcoholic steatohepatitis (NASH), and breast cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 301 Get Quote
5MG 550 Get Quote
10MG 882 Get Quote
25MG 1260 Get Quote
50MG 1702 Get Quote
100MG 2232 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Leronlimab
  • Note
    Research use only, not for human use.
  • Brief Description
    Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody with both anti-HIV and anti-tumor activity, inhibiting CCR-mediated HIV-1 virus and cancer cell metastasis in mouse tumor models. Leronlimab can be used to study HIV, non-alcoholic steatohepatitis (NASH), and breast cancer.
  • Description
    Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. Leronlimab inhibits CCR5-mediated HIV-1 viral and lung metastasis in mouse tumor models. Leronlimab can be used for the research of HIV nonalcoholic steatohepatitis (NASH) and cancer.
  • In Vitro
    Cell Cytotoxicity Assay Cell Line:MDA-MB-231 cell line Concentration:10 μg/mL Incubation Time:72 hours Result:Increased the cells killing effect induced by doxorubicin.
  • In Vivo
    Animal Model:Female NCI Athymic nu/nu nude mice with MB-MDA-231 cells expressing Luc2-eGFP injection Dosage:2 mg Administration:Intraperitoneal injection; 2 mg, twice a week Result:Reduced the volume of pulmonary metastases at 8 weeks.
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    CCR
  • Recptor
    CCR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    674782-26-4
  • Formula Weight
  • Molecular Formula
    ——
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jiao X, et al. Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy. Breast Cancer Res. 2021 Jan 23;23(1):11.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • RS 504393

    RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).

  • Maraviroc

    Maraviroc is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM, respectively.

  • WAY-639418

    WAY-639418 has potential anti-inflammatory and anti-HIV activity and can be used to study CCR5-mediated inflammatory and immunomodulatory diseases.

Sign In Join Free