Tildrakizumab( —— )

Catalog No. M36718 CAS No. 1326244-10-3

Tildrakizumab (SCH 900222) is a potent humanized monoclonal antibody targeting the p19 subunit of IL-23 with a Kd value of 136 pM, useful for studying psoriasis.

Purity : >98% (HPLC)

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Biological Information

Product Name

Tildrakizumab
Note

Research use only, not for human use.
Brief Description

Tildrakizumab (SCH 900222) is a potent humanized monoclonal antibody targeting the p19 subunit of IL-23 with a Kd value of 136 pM, useful for studying psoriasis.
Description

Tildrakizumab (SCH 900222) is a humanized anti-IL-23 (p19 subunit) monoclonal antibody. IL-23 is a critical cytokine to maintain the Th17 cell phenotype. Tildrakizumab has high-affinity for single-chain IL-23 (Kd: 136 pM). Tildrakizumab is effective against moderate to severe plaque psoriasis.
In Vitro

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In Vivo

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Synonyms

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Pathway

Apoptosis
Target

IL Receptor
Recptor

IL Receptor
Research Area

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Indication

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Chemical Information

CAS Number

1326244-10-3
Formula Weight

144.4 (kDa)
Molecular Formula

——
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

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Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Papp K, et al. Tildrakizumab (MK-3222), an anti-interleukin-23p19 monoclonal antibody, improves psoriasis in a phase IIb randomized placebo-controlled trial. Br J Dermatol. 2015 Oct;173(4):930-9. ?

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