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Taurodeoxycholic acid
CAS No. 516-50-7
Taurodeoxycholic acid( —— )
Catalog No. M36631 CAS No. 516-50-7
Taurodeoxycholic acid (Taurodeoxychloic acid) is a bile acid taurine conjugate of deoxycholic acid, a human metabolite that stabilizes mitochondrial membranes and reduces the formation of free radicals.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 85 | In Stock |
|
| 5MG | 112 | In Stock |
|
| 10MG | 162 | In Stock |
|
| 25MG | 264 | In Stock |
|
| 50MG | 428 | In Stock |
|
| 100MG | 614 | In Stock |
|
| 500MG | 1287 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTaurodeoxycholic acid
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NoteResearch use only, not for human use.
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Brief DescriptionTaurodeoxycholic acid (Taurodeoxychloic acid) is a bile acid taurine conjugate of deoxycholic acid, a human metabolite that stabilizes mitochondrial membranes and reduces the formation of free radicals.
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DescriptionTaurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD).
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In Vitro——
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In VivoAnimal Model:Huntington's disease model in mouseDosage:50 mg/kg Administration:Intraperitoneal injection; once daliy for 34 d, injected 3-NP at 6 hr after Taurodeoxycholic acid treatment Result:Reduced striatal atrophy, decreased striatal apoptosis, as well as fewer and smaller size ubiquitinated neuronal intranuclear huntingtin inclusions.Significantly improved locomotor and sensorimotor deficits.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis | Calcium Channel | Caspase
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Research Area——
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Indication——
Chemical Information
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CAS Number516-50-7
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Formula Weight499.7
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Molecular FormulaC26H45NO6S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (200.12 mM; Ultrasonic )
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SMILESC[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])(C[C@@H]1O)[H])[H])(CC[C@@]2([C@@H](CCC(NCCS(=O)(=O)O)=O)C)[H])[H]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Benz C, et al. Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes. Eur J Clin Invest. 2000 Mar;30(3):203-9. ?
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