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Ceftriaxone

CAS No. 73384-59-5

Ceftriaxone( —— )

Catalog No. M36630 CAS No. 73384-59-5

Ceftriaxone is a novel cephalosporin antibiotic with antimicrobial activity against most Gram-positive and Gram-negative bacteria.Ceftriaxone also exhibits anti-inflammatory and antioxidant activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 46 In Stock
5MG 38 In Stock
10MG 53 In Stock
25MG 86 In Stock
50MG 120 In Stock
100MG 172 In Stock
200MG 254 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Ceftriaxone
  • Note
    Research use only, not for human use.
  • Brief Description
    Ceftriaxone is a novel cephalosporin antibiotic with antimicrobial activity against most Gram-positive and Gram-negative bacteria.Ceftriaxone also exhibits anti-inflammatory and antioxidant activity.
  • Description
    Ceftriaxone (Ro 13-9904 free acid) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone is a covalent inhibitor of GSK3β with IC50 value of 0.78 mM. Ceftriaxone is an inhibitor of Aurora B. Ceftriaxone has anti-inflammatory, antitumor and antioxidant activities.Ceftriaxone can be used in the study of bacterial infections and meningitis.
  • In Vitro
    Cell Viability Assay Cell Line:Astrocyte Concentration:100 μM Incubation Time:24 h Result:Improved cell viability and increased glutamate uptake after MPP+ expose.Western Blot Analysis Cell Line:Astrocyte Concentration: 100 μM Incubation Time:24 h Result:Enhanced GLT-1 and GFAP expression.Decreased the expression of p-p50、p-IKKα、p-Relb.
  • In Vivo
    Animal Model:DGL-induced rat modelDosage:200 mg/kg Administration:i.p.Result:Reduced the BUN、Cr 、AST and ALT levels.Attenuated the MDA levels and enhanced GPx and CAT activities.Reduced the levels of IL-1β and TNF-α mRNA.Animal Model:PTZ-induced rat model Dosage:200, 400 mg/kg Administration:i.p. 60 min before to PTZ (70 mg/kg)Result:Both of the two ceftriaxone groups had lower spike percentages than the saline group.Significantly lower MDA levels and higher SOD activity in 200 and 400 mg/kg.
  • Synonyms
    ——
  • Pathway
    Microbiology/Virology
  • Target
    Antifungal
  • Recptor
    Antifungal
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    73384-59-5
  • Formula Weight
    554.58
  • Molecular Formula
    C18H18N8O7S3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 31.25 mg/mL (56.35 mM; Ultrasonic (<60°C)
  • SMILES
    C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC)/C3=CSC(N)=N3)=O)C2=O)(SCC1CSC=4N(C)NC(=O)C(=O)N4)[H]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nahata MC, et al. Ceftriaxone: a third-generation cephalosporin. Drug Intell Clin Pharm. 1985 Dec;19(12):900-6.?
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