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TPE-MI

CAS No. 1245606-71-6

TPE-MI( —— )

Catalog No. M36594 CAS No. 1245606-71-6

TPE-MI (Tetraphenylethene maleimide) is an aggregation-induced luminescent agent that stains living cells, can be used to capture cysteines in exposed unfolded proteins, and detects protein damage after dihydroartemisinin studies of malaria parasites.

Purity : >98% (HPLC)

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Datasheet

HNMR

HPLC

MSDS

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5MG	117	Get Quote
10MG	187	Get Quote
25MG	364	Get Quote
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Biological Information

Product Name

TPE-MI
Note

Research use only, not for human use.
Brief Description

TPE-MI (Tetraphenylethene maleimide) is an aggregation-induced luminescent agent that stains living cells, can be used to capture cysteines in exposed unfolded proteins, and detects protein damage after dihydroartemisinin studies of malaria parasites.
Description

TPE-MI (Tetraphenylethene maleimide) is a thiol probe for measuring unfolded protein load and proteostasis in cells. TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasitesPlasmodium falciparum .
In Vitro

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In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

1245606-71-6
Formula Weight

441.52
Molecular Formula

C31H23NO2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 44.15 mg/mL (100.00 mM; Ultrasonic )
SMILES

O=C1C=CC(=O)N1C2=CC=C(C=C2)C(C=3C=CC=CC3)=C(C=4C=CC=CC4)C5=CC=C(C=C5)C
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Chen MZ, et al. A thiol probe for measuring unfolded protein load and proteostasis in cells. Nat Commun. 2017;8(1):474. Published 2017 Sep 7. ?

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