TSPO ligand-1

Research use only, not for human use.

TSPO ligand-1 has affinity for peripheral and central benzodiazepine receptors.

TSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration.

TSPO ligand-1 gene is induced to increase expression in the context of selective activation of neurons in male C57Bl6/N mice. Moreover, neuronal activation under physiological and psychopharmacological conditions also results in increased TSPO levels in adult mice.TSPO ligand-1 can serve as the sole marker of glial cell activity in Alzheimer’s disease thus tracking the formation of different neural cells.TSPO ligand-1 can regulate mitochondrial fatty acid oxidation (FAO) and thus effects mitochondrial energy homeostasis in MA-10 Leydig cell line.

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Autophagy

Autophagy

Autophagy | Ligands for Target Protein for PROTAC

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4560-08-1

283.71

C16H10ClNO2

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (440.59 mM; Ultrasonic )

O=C(Cl)C(=O)C=1C=2C=CC=CC2NC1C=3C=CC=CC3

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(-20℃)

With Ice Pack

≥ 2 years