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SMER-18
CAS No. 944153-47-3
SMER-18( SMER18 )
Catalog No. M16762 CAS No. 944153-47-3
A small molecule autophagy enhancer that induces autophagy independently of rapamycin in mammalian cells and enhances the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein; reduces toxicity in Huntington's disease models.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 360 | In Stock |
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| 5MG | 330 | In Stock |
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| 10MG | 471 | In Stock |
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| 25MG | 914 | In Stock |
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| 50MG | 1386 | In Stock |
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| 100MG | 1841 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSMER-18
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NoteResearch use only, not for human use.
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Brief DescriptionA small molecule autophagy enhancer that induces autophagy independently of rapamycin in mammalian cells and enhances the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein; reduces toxicity in Huntington's disease models.
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DescriptionA small molecule autophagy enhancer that induces autophagy independently of rapamycin in mammalian cells and enhances the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein; reduces toxicity in Huntington's disease models.
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In Vitro——
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In Vivo——
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SynonymsSMER18
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number944153-47-3
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Formula Weight287.7409
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Molecular FormulaC16H14ClNO2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESOC1=C2N=C(C)C=CC2=CC=C1C(NC3=NC=CC(C)=C3)C4=CC=CC=C4[N+]([O-])=O
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Chemical Name2-Buten-1-one, 1-(4-chlorophenyl)-3-[(3-hydroxyphenyl)amino]-, (2Z)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sarkar S, et al. Nat Chem Biol. 2007 Jun;3(6):331-8.
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