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CLK8
CAS No. 898920-65-5
CLK8( —— )
Catalog No. M36544 CAS No. 898920-65-5
CLK8 is a selective CLOCK inhibitor that binds to and interferes with CLOCK activity, disrupts the interaction between CLOCK and BMAL1, and modulates circadian rhythm amplitude.CLK8 can be used to study circadian rhythm-related disorders.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCLK8
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NoteResearch use only, not for human use.
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Brief DescriptionCLK8 is a selective CLOCK inhibitor that binds to and interferes with CLOCK activity, disrupts the interaction between CLOCK and BMAL1, and modulates circadian rhythm amplitude.CLK8 can be used to study circadian rhythm-related disorders.
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DescriptionCLK8 is a potent and specific CLOCK inhibitor that can disrupt the interaction between CLOCK and BMAL1 and interfere with nuclear translocation of CLOCK. CLK8 can be used for the research of disorders associated with dampened circadian rhythms.
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In Vitro——
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In VivoAnimal Model:Male C57BL/6J mice (8 weeks, 18-24 g)Dosage:25 mg/kg Administration:A single i.p.Result:A decrease in CLOCK levels was detected in whole cell lysates of the mouse livers, whereas the levels of BMAL1 and CRY1 were unaltered.Decreased the abundance of CLOCK in the nucleus.The abundances of cytosolic and nuclear BMAL1 and CRY1 were unaltered.Decreased Cry1 transcriptional level.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number898920-65-5
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Formula Weight498.53
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Molecular FormulaC29H26N2O6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (100.29 mM; Ultrasonic )
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SMILESO=C1OC2=C(C(OCC(=O)NC=3C=CC=CC3C(=O)N)=CC=4OC(C)(C)CCC42)C(=C1)C=5C=CC=CC5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Doruk YU, et, al. A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude. J Biol Chem. 2020 Mar 13;295(11):3518-3531. ?
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