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TH-Z145

CAS No. 2260887-57-6

TH-Z145( —— )

Catalog No. M36529 CAS No. 2260887-57-6

TH-Z145 is a potent FPPS inhibitor for the study of myeloma and lung cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 67 In Stock
5MG 100 In Stock
10MG 163 In Stock
25MG 327 In Stock
50MG 526 In Stock
100MG 822 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    TH-Z145
  • Note
    Research use only, not for human use.
  • Brief Description
    TH-Z145 is a potent FPPS inhibitor for the study of myeloma and lung cancer.
  • Description
    TH-Z145, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 210 nM).
  • In Vitro
    ——
  • In Vivo
    TH-Z145 (20 μg, i.p.) exhibits strong prophylactic effects in a pathogenic influenza model.Animal Model:B16-OVA cells (s.c.) xenograft mice model.Dosage:20 μg Administration:Intraperitoneal injection (i.p.)Result:Inhibited tumor growth and prolonged survival.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2260887-57-6
  • Formula Weight
    394.34
  • Molecular Formula
    C16H28O7P2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (253.59 mM; Ultrasonic )
  • SMILES
    C(C(P(=O)(O)O)P(=O)(O)O)C1=CC(OCCCCCCCC)=CC=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xia Y, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Nov 1;175(4):1059-1073.e21. ?
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