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Dimethyl malonate
CAS No. 108-59-8
Dimethyl malonate( —— )
Catalog No. M20375 CAS No. 108-59-8
Dimethyl Malonate is a Succinate Dehydrogenase inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 500MG | 38 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameDimethyl malonate
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NoteResearch use only, not for human use.
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Brief DescriptionDimethyl Malonate is a Succinate Dehydrogenase inhibitor.
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DescriptionDimethyl Malonate is a Succinate Dehydrogenase inhibitor.
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In Vitro——
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In VivoAnimal Model:Sprague-Dawley male rats, cardiac arrest modelDosage:6 mg/kg/minAdministration:Intravenous infusion, 51 minResult:Improved ROSC after CA. Prevented the decline in neurological function and inhibited the apoptosis of hippocampal neurons at day 3 after CPR. Inhibited caspase-3 cleavage and increased HIF-1α expression at day 3 after CPR. Decreased the level of oxidative stress at day 3 after CPR. Inhibited excessive hyperpolarization of MMP and restrained the leakage of cytochrome C after 45 min reperfusion.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorSuccinate Dehydrogenase
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Research Area——
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Indication——
Chemical Information
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CAS Number108-59-8
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Formula Weight132.11
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Molecular FormulaC5H8O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (756.94 mM)
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SMILESCOC(=O)CC(=O)OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Xu J Pan H Xie X et .al.Inhibiting Succinate Dehydrogenase by Dimethyl Malonate Alleviates Brain Damage in a Rat Model of Cardiac Arrest[J].Neuroscience. 2018 Nov 21;393:24-32
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