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PHGDH-IN-3

CAS No. 2893778-31-7

PHGDH-IN-3( —— )

Catalog No. M36500 CAS No. 2893778-31-7

PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH, and it can be used in cancer research.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PHGDH-IN-3
  • Note
    Research use only, not for human use.
  • Brief Description
    PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH, and it can be used in cancer research.
  • Description
    PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor. PHGDH-IN-3 inhibits PHGDH with an IC50 value of 2.8 μM. PHGDH-IN-3 can be used for the research of cancer.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Balb/c nude mice Dosage:12.5, 25, 50 mg/kg Administration:Intraperitoneal (i.p.); once daily for consecutive 31 days Result:Exhibited an in vivo anti-tumor effect and significantly delayed the tumor growth.Significantly abated the tumor weights of mice at 25 mg/ kg.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    Dehydrogenase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2893778-31-7
  • Formula Weight
    495.55
  • Molecular Formula
    C24H18FN3O4S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (201.80 mM; Ultrasonic (<70°C)
  • SMILES
    N(C(=O)C1=CC=C(S(NC2=CC(C(C)=O)=CC=C2)(=O)=O)C=C1)C3=NC(=CS3)C4=CC(F)=CC=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dingding Gao, et al. Discovery of Novel Drug-like PHGDH Inhibitors to Disrupt Serine Biosynthesis for Cancer Therapy. J Med Chem. 2023 Jan 12;66(1):285-305.?
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