Darizmetinib( —— )

Catalog No. M36482 CAS No. 2369583-33-3

Darizmetinib (HRX215, HRX-0215) is an MKK4 inhibitor. Inhibition of MKK4 leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and liver regeneration.

Purity : >98% (HPLC)

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Datasheet

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Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	151	In Stock
2MG	91	In Stock
5MG	150	In Stock
10MG	236	In Stock
25MG	342	In Stock
50MG	414	In Stock
100MG	606	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

Darizmetinib
Note

Research use only, not for human use.
Brief Description

Darizmetinib (HRX215, HRX-0215) is an MKK4 inhibitor. Inhibition of MKK4 leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and liver regeneration.
Description

Darizmetinib is an inhibitor of mitogen-activated protein kinase kinase (MAP2K).
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

p38 MAPK
Recptor

MAPK | Antiviral
Research Area

——
Indication

——

Chemical Information

CAS Number

2369583-33-3
Formula Weight

457.45
Molecular Formula

C21H17F2N5O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=NNC2=NC=C(C=C21)C=3C=CN=CC3)C4=CC=C(F)C(NS(=O)(=O)CCC)=C4F
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Praefke B, et al. Preparation of pyrazolopyridines as protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death: World Intellectual Property Organization, WO2019149738. 2019-08-08.

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