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Darizmetinib
CAS No. 2369583-33-3
Darizmetinib( —— )
Catalog No. M36482 CAS No. 2369583-33-3
Darizmetinib (HRX215, HRX-0215) is an MKK4 inhibitor. Inhibition of MKK4 leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and liver regeneration.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 151 | In Stock |
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| 2MG | 91 | In Stock |
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| 5MG | 150 | In Stock |
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| 10MG | 236 | In Stock |
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| 25MG | 342 | In Stock |
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| 50MG | 414 | In Stock |
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| 100MG | 606 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDarizmetinib
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NoteResearch use only, not for human use.
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Brief DescriptionDarizmetinib (HRX215, HRX-0215) is an MKK4 inhibitor. Inhibition of MKK4 leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and liver regeneration.
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DescriptionDarizmetinib is an inhibitor of mitogen-activated protein kinase kinase (MAP2K).
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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RecptorMAPK | Antiviral
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Research Area——
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Indication——
Chemical Information
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CAS Number2369583-33-3
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Formula Weight457.45
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Molecular FormulaC21H17F2N5O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=NNC2=NC=C(C=C21)C=3C=CN=CC3)C4=CC=C(F)C(NS(=O)(=O)CCC)=C4F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Praefke B, et al. Preparation of pyrazolopyridines as protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death: World Intellectual Property Organization, WO2019149738. 2019-08-08.
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