Darizmetinib( —— )

Catalog No. M36482 CAS No. 2369583-33-3

Darizmetinib (HRX215, HRX-0215) is an MKK4 inhibitor. Inhibition of MKK4 leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and liver regeneration.

Purity : >98% (HPLC)

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Size	Price / USD	Stock	Quantity
2MG	236	Get Quote
5MG	367	Get Quote
10MG	588	Get Quote
25MG	1187	Get Quote
50MG	1822	Get Quote
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Biological Information

Product Name

Darizmetinib
Note

Research use only, not for human use.
Brief Description

Darizmetinib (HRX215, HRX-0215) is an MKK4 inhibitor. Inhibition of MKK4 leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and liver regeneration.
Description

Darizmetinib is an inhibitor of mitogen-activated protein kinase kinase (MAP2K).
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

p38 MAPK
Recptor

MAPK | Antiviral
Research Area

——
Indication

——

Chemical Information

CAS Number

2369583-33-3
Formula Weight

457.45
Molecular Formula

C21H17F2N5O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=NNC2=NC=C(C=C21)C=3C=CN=CC3)C4=CC=C(F)C(NS(=O)(=O)CCC)=C4F
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Praefke B, et al. Preparation of pyrazolopyridines as protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death: World Intellectual Property Organization, WO2019149738. 2019-08-08.

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