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p53 Activator 7
CAS No. 2849340-59-4
p53 Activator 7( —— )
Catalog No. M36474 CAS No. 2849340-59-4
p53 Activator 7 is a highly potent and cell-permeable activator of the p53 mutation Y220C (MDM-2/p53), which induces apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 714 | In Stock |
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| 5MG | 629 | In Stock |
|
| 10MG | 1017 | In Stock |
|
| 25MG | 1511 | In Stock |
|
| 50MG | 2000 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Namep53 Activator 7
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NoteResearch use only, not for human use.
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Brief Descriptionp53 Activator 7 is a highly potent and cell-permeable activator of the p53 mutation Y220C (MDM-2/p53), which induces apoptosis.
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Descriptionp53 Activator 7 is a p53 mutation Y220C (MDM-2/p53) activator with an EC50 of 104 nM. p53 Activator 7 can bind to p53 mutant and restore its ability to bind DNA (WO2022213975A1; Example B-1). p53 Activator 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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In VitroThe p53 protein, referred to as the “guardian of the human genome” , is a tetrameric transcription factor that prevents mutation to the genome by regulating the expression of a subgroup of target genes. Although biologically active as a homotetramer, each p53 monomer is comprised of 393 amino acids, and is divided into five key regulatory domains: the transactivation domain (TAD) , proline-rich region (PR) , the DNA binding domain (DBD) , the oligomerization domain (OD) , and the C-terminus.
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number2849340-59-4
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Formula Weight516.538
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Molecular FormulaC27H32F3N4OP
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (193.60 mM; Ultrasonic )
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SMILESO=P(C1=CC=C(C=C1)NCC#CC2=CC=3C(=CC=CC3N2CC(F)(F)F)NC4CCN(C)CC4)(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sujing LI, et al. Compounds targeting y220c mutant of p53. WO2022213975A1.
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