p53 Activator 7

Research use only, not for human use.

p53 Activator 7 is a highly potent and cell-permeable activator of the p53 mutation Y220C (MDM-2/p53), which induces apoptosis.

p53 Activator 7 is a p53 mutation Y220C (MDM-2/p53) activator with an EC50 of 104 nM. p53 Activator 7 can bind to p53 mutant and restore its ability to bind DNA (WO2022213975A1; Example B-1). p53 Activator 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

The p53 protein, referred to as the “guardian of the human genome” , is a tetrameric transcription factor that prevents mutation to the genome by regulating the expression of a subgroup of target genes. Although biologically active as a homotetramer, each p53 monomer is comprised of 393 amino acids, and is divided into five key regulatory domains: the transactivation domain (TAD) , proline-rich region (PR) , the DNA binding domain (DBD) , the oligomerization domain (OD) , and the C-terminus.

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Apoptosis

Apoptosis

Apoptosis

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2849340-59-4

516.538

C27H32F3N4OP

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (193.60 mM; Ultrasonic )

O=P(C1=CC=C(C=C1)NCC#CC2=CC=3C(=CC=CC3N2CC(F)(F)F)NC4CCN(C)CC4)(C)C

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(-20℃)

With Ice Pack

≥ 2 years