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H2-Gamendazole

CAS No. 877768-84-8

H2-Gamendazole( —— )

Catalog No. M36435 CAS No. 877768-84-8

H2-Gamendazole is a novel compound for spermatogenesis inhibition and cancer therapy as an inhibitor of heat shock proteins and/or elongation factor 1 alpha, and is an Hsp90 regulator.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 181 Get Quote
5MG 316 Get Quote
10MG 473 Get Quote
25MG 814 Get Quote
50MG 1095 Get Quote
100MG 1467 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
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Biological Information

  • Product Name
    H2-Gamendazole
  • Note
    Research use only, not for human use.
  • Brief Description
    H2-Gamendazole is a novel compound for spermatogenesis inhibition and cancer therapy as an inhibitor of heat shock proteins and/or elongation factor 1 alpha, and is an Hsp90 regulator.
  • Description
    H2-Gamendazole is a derivative of Lonidamine that reduces cyst formation in polycystic kidney disease and is used in autosomal dominant polycystic kidney disease research.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    877768-84-8
  • Formula Weight
    417.21
  • Molecular Formula
    C18H13Cl2F3N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (299.61 mM; Ultrasonic (<60°C)
  • SMILES
    C(N1C=2C(C(CCC(O)=O)=N1)=CC=C(C(F)(F)F)C2)C3=C(Cl)C=C(Cl)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shirin V Sundar, et al. The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease. Am J Physiol Renal Physiol. 2022 Oct 1;323(4):F492-F506.??
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