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KYN-101

CAS No. 2247950-73-6

KYN-101( —— )

Catalog No. M36421 CAS No. 2247950-73-6

KYN-101 is an orally active and selective aryl hydrocarbon receptor (AHR) inhibitor with anticancer activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KYN-101
  • Note
    Research use only, not for human use.
  • Brief Description
    KYN-101 is an orally active and selective aryl hydrocarbon receptor (AHR) inhibitor with anticancer activity.
  • Description
    KYN-101 is a potent, selective and orally active AHR inhibitor. KYN-101 decreases the CYP1A1 mRNA expression. KYN-101 shows anti-cancer activity.
  • In Vitro
    ——
  • In Vivo
    Animal Model:6-8 weeks, C57BL/6J mice (B16IDO tumor-bearing mice)Dosage:10 mg/kg Administration:P.o.; daily for 12 days Result:Reduced tumor growth in B16IDO tumor-bearing mice and combination of KYN-101 and anti-PD-1 led to improved tumor growth delay and extended survival in CT26 models.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    AhR
  • Recptor
    AhR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2247950-73-6
  • Formula Weight
    386.43
  • Molecular Formula
    C22H19FN6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (258.79 mM; Ultrasonic )
  • SMILES
    FC1=CN=CC(=C1)C2=NC3=C(C=NN3C(=C2)NCCC4=CNC=5C=CC=CC54)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Campesato LF, et al. Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine. Nat Commun. 2020 Aug 11;11(1):4011.?
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