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Pinokalant
CAS No. 149759-26-2
Pinokalant( —— )
Catalog No. M36347 CAS No. 149759-26-2
Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabolic and electrophysiological status of the ischemic penumbra region.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 409 | Get Quote |
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| 10MG | 604 | Get Quote |
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| 25MG | 938 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePinokalant
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NoteResearch use only, not for human use.
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Brief DescriptionPinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabolic and electrophysiological status of the ischemic penumbra region.
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DescriptionPinokalant is a broad-spectrum and non-selectivecation channel inhibitor. Pinokalant significantly reduces cortical infarct volume. Pinokalant o improves the metabolic and electrophysiologic status of the ischemic penumbra. Pinokalant reduces lesion size on magnetic resonance images in the acute phase following middle cerebral artery occlusion in rats. Pinokalant has the potential for the research of stroke. Pinokalant also shows anti-SARS-CoV-2 activity.
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In Vitro——
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In VivoPinokalant significantly reduces cortical infarct volume from 33.8 mm3 to 24.5 mm3.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorTRP/TRPV Channel | SARS-CoV
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Research Area——
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Indication——
Chemical Information
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CAS Number149759-26-2
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Formula Weight712.83
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Molecular FormulaC41H48N2O9
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Purity>98% (HPLC)
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Solubility——
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SMILESC(C(N(CCC1=C(OC)C(OC)=C(OC)C=C1)CCC2=C(OC)C(OC)=C(OC)C=C2)=O)(C=3C=4C(=CC(OC)=C(OC)C4)CCN3)C5=CC=CC=C5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Christensen T, et al. The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain infarct volume in rats: a temperature-controlled histological study. Basic Clin Pharmacol Toxicol. 2005 Apr;96(4):316-24. ?
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