Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - TRP/TRPV Channel - SET 2

SET 2

CAS No. 2313525-20-9

SET 2( —— )

Catalog No. M34914 CAS No. 2313525-20-9

SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 62 In Stock
5MG 50 In Stock
10MG 84 In Stock
25MG 178 In Stock
50MG 294 In Stock
100MG 429 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    SET 2
  • Note
    Research use only, not for human use.
  • Brief Description
    SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.
  • Description
    SET2 is a selective TRPV2 antagonist (IC50=0.46 μM). SET2 blocks the TRP channel and suppresses prostate cancer cells migration. SET2 reduces the lysophosphatidic acid (LPA, a TRPV2 activator)-induced cytoplasmic calcium increases.
  • In Vitro
    Cell Migration Assay Cell Line:PC-3M prostate cancer cells Concentration:0, 5 μM, 10 μM, and 20 μM Incubation Time:24 hr and 48 hr Result:Inhibited cell migration of PC-3M cells, without inhibiting cell viability at 48 hours.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRP/TRPV Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2313525-20-9
  • Formula Weight
    402.43
  • Molecular Formula
    C17H21F3N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (248.49 mM; Ultrasonic (<60°C)
  • SMILES
    CCCN(C)c1cc(nc(SCCC(=O)NCc2ccco2)n1)C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chai H, et al. Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel. J Med Chem. 2019 Feb 14;62(3):1373-1384. ?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • GSK1702934A

    GSK1702934A, a selective TRPC3 agonist, modulates cardiac contractility and arrhythmogenesis through TRPC3 activation.

  • Pyr6

    Pyr6 is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).Pyr6 is an inhibitor of Ca2+ entry, which displays higher potency to inhibit Ca2+ entry mediated by CRAC channel than by TRPC3.Pyr3 is selective inhibitor of TRPC3, inhibited Orai1- and TRPC3-mediated Ca(2+) entry and currents as well as mast cell activation with similar potency.?

  • TETRAHYDROPIPERINE

    TETRAHYDROPIPERINE is a natural product derived from piperine can be used to treat convulsion epilepsy relieve pain and control insects.

Sign In Join Free