Suzetrigine( —— )

Catalog No. M36286 CAS No. 2649467-58-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Suzetrigine
Note

Research use only, not for human use.
Brief Description

Suzetrigine（VX-548） is an orally active and specific NaV1.8 inhibitor. Suzetrigine has analgesic activity and can be used to study acute pain and neurotransmission.
Description

Suzetrigine (VX-548) is an orally active and highly selective NaV1.8 inhibitor that acts as an analgesic. Suzetrigine is also a blocker of sodium channel protein type 10 subunit alpha.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Membrane Transporter/Ion Channel
Target

Sodium Channel
Recptor

Sodium Channel
Research Area

——
Indication

——

CAS Number

2649467-58-1
Formula Weight

473.39
Molecular Formula

C21H20F5N3O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (264.05 mM; Ultrasonic )
SMILES

C(NC=1C=C(C(N)=O)N=CC1)(=O)[C@H]2[C@@H]([C@H](C)[C@@]([C@@](F)(F)F)(C)O2)C3=C(OC)C(F)=C(F)C=C3
Chemical Name

——

1. Jones J, et al. Selective Inhibition of NaV1.8 with VX-548 for Acute Pain. N Engl J Med. 2023 Aug 3;389(5):393-405.?

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