Cart
sales@molnova.com
Home - Products - Apoptosis - Apoptosis - CWI1-2

CWI1-2

CAS No. 2408590-36-1

CWI1-2( —— )

Catalog No. M36087 CAS No. 2408590-36-1

CWI1-2 is a potent IGF2BP2 inhibitor that inhibits its interaction with M6A-modified target transcripts by binding IGF2BP2. CWI1-2 has anti-leukemic activity and can induce apoptosis and differentiation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 93 In Stock
10MG 148 In Stock
25MG 297 In Stock
50MG 423 In Stock
100MG 600 In Stock
200MG 825 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    CWI1-2
  • Note
    Research use only, not for human use.
  • Brief Description
    CWI1-2 is a potent IGF2BP2 inhibitor that inhibits its interaction with M6A-modified target transcripts by binding IGF2BP2. CWI1-2 has anti-leukemic activity and can induce apoptosis and differentiation.
  • Description
    CWI1-2 is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects.
  • In Vitro
    Apoptosis AnalysisCell Line:MonoMac6, MOLM13Concentration:0-1 μM Incubation Time:24 h Result:Induced significant cell differentiation and apoptosis in a concentration-dependent manner in IGF2BP2-high cells but not in IGF2BP2-low cells. Reduced Gln uptake and impaired mitochondrial function, resulting in reduced ATP production in AML cells. Significantly inhibited the colony-forming ability of MA9-induced leukemic mouse blasts and greatly impairs the self-renewal of LSC/LIC.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2408590-36-1
  • Formula Weight
    519.77
  • Molecular Formula
    C22H17Cl3N6O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (192.39 mM; Ultrasonic )
  • SMILES
    ClC1=CC=C(O)C(C=NN=C(NN=CC2=CC(Cl)=CC=C2O)NN=CC3=CC(Cl)=CC=C3O)=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hengyou Weng, et al. The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. Cancer Cell. 2022 Dec 12;40(12):1566-1582.e10.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • BC 11 hydrobromide

    BC 11 hydrobromide is a selective TMPRSS2 and urokinase (uPA) inhibitor.BC-11 induces diminished mitochondrial activity, promotes reactive oxygen species production, and promotes apoptosis, and can be used in the study of breast cancer.

  • Millepachine

    Millepachine is a natural product found in the Chinese herbal medicine with strong antitumor effects against numerous human cancer cells.

  • Mardepodect hydrochl...

    Mardepodect hydrochloride (Mardepodect HCl) is an orally active, selective and potent inhibitor of PDE10A that crosses the blood-brain barrier (IC50: 0.37 nM).

Sign In Join Free