CB2 receptor agonist 2

Research use only, not for human use.

CB2 receptor agonist 2 is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor, Ki = 8.5 nM. CB2 receptor agonist 2 has high affinity and selectivity for CB2.

CB2 receptor agonist 2 is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor, Ki = 8.5 nM. CB2 receptor agonist 2 has high affinity and selectivity for CB2.(In Vitro):CB2 receptor agonist 2 (compound 4g) (1 μM; 72 hours) shows low or no cytotoxicity to Hep-G2 cells.(In Vivo):CB2 receptor agonist 2 (compound 4g) (1 and 3 mg/kg; 1 hour) is very potent (with maximal effect being reached already at the 1 mg/kg dose) and has antihyperalgesic effects, efficacious also on the first phase of the nocifensive response and strongly reduced by AM630, a CB2-selective antagonist/inverse agonist .

CB2 receptor agonist 2 (compound 4g) (1 ?μM; 72 hours) has very low or no cytotoxicity to Hep-G2 cells. Cell Proliferation Assay Cell Line:Hep-G2 (Human hepatoblastoma) cells Concentration:1 ?μM Incubation Time:72 hours Result:Exhibited very low or no cytotoxicity to Hep-G2 cells.

CB2 receptor agonist 2 (compound 4g) (1 and 3 mg/kg; 1 hour) is very potent (with maximal effect being reached already at the 1 mg/kg dose) and has antihyperalgesic effects, efficacious also on the first phase of the nocifensive response and strongly reduced by AM630 (CB2-selective antagonist/inverse agonist) . Animal Model:Formalin injection induces a biphasic stereotypical nocifensive behavior in miceDosage:Formalin (1.25% in saline, 30 μL), 1 and 3 mg/kg CB2 receptor agonist 2, 1 mg/kg AM630, monitor every 5 minutes for 1 hour Administration:Injection in the dorsal surface of one side of the hindpaw (Formalin), i.p. (CB2 receptor agonist, AM630)Result:Elicited antihyperalgesic effects and potent (with maximal effect being reached already at the 1 mg/kg dose) and efficacious, strongly reduced by AM630.

4-Quinolone-3-Carboxamide Furan CB2 Agonist | ZINC72105556

GPCR/G Protein

Cannabinoid Receptor

Trypanosoma cruzi

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1314230-75-5

488.62

C30H36N2O4

>98% (HPLC)

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O=C(NC12CC3CC(CC(C3)C1)C2)C4=CN(C=5C(OC)=CC(=CC5C4=O)C=6OC=CC6)CCCCC

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(-20℃)

With Ice Pack

≥ 2 years