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BMY-14802
CAS No. 105565-56-8
BMY-14802( —— )
Catalog No. M35949 CAS No. 105565-56-8
BMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) is a selective and orally active sigma-1 antagonist with an IC50 of 112 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 52 | Get Quote |
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| 5MG | 76 | Get Quote |
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| 10MG | 132 | Get Quote |
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| 25MG | 256 | Get Quote |
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| 50MG | 419 | Get Quote |
|
| 100MG | 605 | Get Quote |
|
| 500MG | 1287 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBMY-14802
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NoteResearch use only, not for human use.
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Brief DescriptionBMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) is a selective and orally active sigma-1 antagonist with an IC50 of 112 nM.
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DescriptionBMY 14802 is a sigma-1 receptor (σ1R) antagonist, as well as an agonist at serotonin (5-HT) 1A and adrenergic alpha-1 receptors. BMY 14802 inhibits abnormal involuntary movement (AIM) in rat Parkinson's disease (PD) model, with down-regulating the expression of AIM.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAutophagy
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TargetSigma receptor
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RecptorSigma receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number105565-56-8
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Formula Weight348.39
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Molecular FormulaC18H22F2N4O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (143.52 mM; Ultrasonic (<60°C)
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SMILESOC(CCCN1CCN(CC1)c1ncc(F)cn1)c1ccc(F)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Paquette MA, et al. The sigma-1 antagonist BMY-14802 inhibits L-DOPA-induced abnormal involuntary movements by a WAY-100635-sensitive mechanism. Psychopharmacology (Berl). 2009 Jul;204(4):743-54. ?
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