Vitamin E succinate

Research use only, not for human use.

Vitamin E succinate (D-alpha-Tocopherol Succinate) is an antioxidant tocopherol that belongs to the vitamin E class of compounds Vitamin E succinate has antitumor activity, induces apoptosis, and is used as an adjuvant in the treatment of cancer and in the synthesis of INVITE, a biocoupling compound.

D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer.

D-α-Tocopherol Succinate (1-20 μM; 24 hours) shows cytotoxicity to HEI-OC1 cells.D-α-Tocopherol Succinate (10 μM; 48 hours) protects HEI-OC1 cells against cisplatin-induced ototoxicity and inhibits caspase-3 activity.D-α-Tocopherol Succinate (0-50 μM; 18 hours) shows cytotoxicity to TC-1 tumor cells.Cell Cytotoxicity Assay Cell Line:HEI-OC1 cell line Concentration:1-20 μM Incubation Time:24 hoursResult:Significantly induced cytotoxicity at a concentration of 20 μM and showed a higher cytotoxicity potency compared with 10 μM.Cell Viability Assay Cell Line:HEI-OC1 cell line Concentration:10 μM Incubation Time:48 hours Result:Increased cisplatin-induced cell population. Inhibited cisplatin-induced necrotic, ROS production and late apoptosis. Decreased cleaved PARP and inhibited the expression of caspase-3 which related to cisplatin-induced apoptosis.Cell Cytotoxicity Assay Cell Line:TC-1 tumor cells Concentration:0, 25 and 50 μM Incubation Time:18 hours Result:Dose-dependently showed cytotoxic and induced a higher percentage of necrotic TC-1 cells as opposed to apoptotic cells.

D-α-Tocopherol Succinate (1-2 mg/kg; i.p. three times at 2 day intervals from TC-1 tumor cells injection for 10 days to 14 days) shows antitumor effects to mice with TC-1 tumor.Animal Model:Six- to eight-week-old female C57BL/6 mice with TC-1 tumor cellsDosage:1 and 2 mg/kg Administration:Intraperitoneal injection; 1 and 2 mg/kg three times at 2 day intervals; from TC-1 tumor cells injection for 10 days to 14 days Result:Dreased the tumor volume, especially with a dose of 2 mg/kg.

——

Apoptosis

Apoptosis

Apoptosis

——

——

4345-03-3

530.78

C33H54O5

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (471.00 mM; Ultrasonic )

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(=O)CCC(O)=O)c(C)c(C)c2O1

——

(-20℃)

With Ice Pack

≥ 2 years