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TJ191
CAS No. 1522415-97-9
TJ191( —— )
Catalog No. M23656 CAS No. 1522415-97-9
TJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
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| 10MG | 30 | In Stock |
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| 25MG | 50 | In Stock |
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| 50MG | 73 | In Stock |
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| 100MG | 109 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTJ191
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NoteResearch use only, not for human use.
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Brief DescriptionTJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.
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DescriptionTJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.
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In VitroTJ191(0-100 μM; 24 hours) exhibits pronounced anti-proliferative activity in malignant?cell?lines, the IC50 values are 0.13 μM, 0.13±0.08 μM, 0.26±0.19 μM, 0.22±0.11 μM, 1.5±0.02 μM, 0.32±0.086 μM, 3.1±0.5 μM, 0.26±0.16 μM in CEM, JURKAT, MOLT-3, MOLT-4, SUP-T1, MT-2, C8166 and HSB-2 cells, respectively. But has no effects in HUT-78 (IC50=17±10 μM) and MT-4 (IC50=47 ± 5 μM) cells.TJ191 (0.1-3 μM; 8 or 24 hours) induces CEM cell apoptosis in a concentration- and time-dependent manner. Even at 0.3 μM, TJ191 induces the maximum apoptotic rate of 80% after 24 h. Cell Viability Assay Cell Line:Malignant T-cell leukemia/lymphoma cells Concentration:0.01 μM, 0.1 μM, 1 μM, 10 μM, 100 μM Incubation Time:24 hours Result:Exhibited inhibitory effects in drug-sensitive cells with IC50 ranging 0.13 μM to 3.1 μM. Apoptosis Analysis Cell Line:CEM cell line Concentration:0.1-3 μM Incubation Time:8 or 24 hoursResult:Led to cell apoptosis.
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number1522415-97-9
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Formula Weight255.38
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Molecular FormulaC13H21NO2S
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESCCCCCCCC1=CC(C(OC)=O)=C(N)S1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ahmed El-Gazzar, et al. 2-Amino-3-methylcarboxy-5-heptyl-thiophene (TJ191) is a selective anti-cancer small molecule that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells. Oncotarget. 2017 Dec 15;9(5):6259-6269.
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