Cbl-b-IN-3( —— )

Catalog No. M35743 CAS No. 2573775-59-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Cbl-b-IN-3
Note

Research use only, not for human use.
Brief Description

Cbl-b-IN-3 is a potent inhibitor of casitas b lineage lymphoma proto-oncogene-b (Cbl-b) (ic50 < 1 nM).
Description

Cbl-b-IN-3 (Compound 23) is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 of < 1 nM. Cbl-b is an E3 ubiquitin ligase that negatively regulates T-cell activation.
In Vitro

Cbl-b-IN-3 (Compound 23) enhances IL-2 secretion by T-cells stimulated with an anti-CD3 antibody alone or in combination with an anti-CD28 antibody.
In Vivo

——
Synonyms

——
Pathway

Proteasome/Ubiquitin
Target

E1
Recptor

E1/E2/E3 Enzyme
Research Area

——
Indication

——

CAS Number

2573775-59-2
Formula Weight

537.62
Molecular Formula

C30H34F3N5O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (186.00 mM; Ultrasonic )
SMILES

CN1C([C@]2(C[C@@H](C)C2)C3=CC(=CC=C3)N4CC=5C(C4=O)=CC(CN6C[C@@H](C)CCC6)=CC5C(F)(F)F)=NN=C1
Chemical Name

——

1. Arthur T. Sands, et al. Substituted benzyl-triazole compounds for cbl-b inhibition, and further uses thereof. WO2020264398A1.

Calculator

molnova catalog