NRX-103095( —— )

Catalog No. M35736 CAS No. 2763260-38-2

NRX-103095 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP and enhances the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 163 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	427	In Stock
5MG	364	In Stock
10MG	588	In Stock
25MG	1169	In Stock
50MG	1841	In Stock
100MG	2762	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

NRX-103095
Note

Research use only, not for human use.
Brief Description

NRX-103095 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP and enhances the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 163 nM.
Description

NRX-103095 is an enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103095 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 163 nM.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Wnt/Notch/Hedgehog
Target

Wnt/beta/catenin
Recptor

Wnt/beta-catenin
Research Area

——
Indication

——

Chemical Information

CAS Number

2763260-38-2
Formula Weight

530.35
Molecular Formula

C22H16Cl2F3N3O3S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (188.55 mM; Ultrasonic )
SMILES

S(C1=C(C(NC2=CC(C(N(C)C)=O)=CC=C2)=O)C(=O)NC(C(F)(F)F)=C1)C3=C(Cl)C=CC=C3Cl
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402.?

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