Cart
sales@molnova.com
DK419
CAS No. 2102672-22-8
DK419( —— )
Catalog No. M26671 CAS No. 2102672-22-8
DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 164 | In Stock |
|
| 10MG | 259 | In Stock |
|
| 25MG | 428 | In Stock |
|
| 50MG | 591 | In Stock |
|
| 100MG | 798 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameDK419
-
NoteResearch use only, not for human use.
-
Brief DescriptionDK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.
-
DescriptionDK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK.(In Vitro):DK419 inhibited the growth of CRC tumor cells in vitro and had good plasma exposure when dosed orally.(In Vivo):DK419 inhibited the growth of patient derived CRC240 tumor explants in mice dosed orally.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayWnt/Notch/Hedgehog
-
TargetWnt/beta/catenin
-
RecptorLDL| UGT1A1
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2102672-22-8
-
Formula Weight407.7
-
Molecular FormulaC16H8ClF6N3O
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 83.33 mg/mL (204.39 mM)
-
SMILESFC(F)(F)c1nc2cc(Cl)cc(C(=O)Nc3ccc(cc3)C(F)(F)F)c2[nH]1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Ngoc TM, et al. Antioxidative activities of galloyl glucopyranosides from the stem-bark of Juglans mandshurica. Biosci Biotechnol Biochem. 2008 Aug;72(8):2158-63.
molnova catalog
related products
-
TNIK-IN-2
TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.
-
Ipafricept
Ipafricept (OMP-54F28) is a recombinant fusion protein consisting of the extracellular portion of the human frizzled-8 receptor fused to a fragment of human IgG1 Fc, and a Wnt inhibitor that blocks Wnt signaling.
-
IWP-3
IWP-3 is a potent inhibitor of Wnt production with an IC50 of 40 nM. It inhibits Porcupine (Porcn), blocking the palmitoylation of Wnt proteins, and moderately inhibits CK1γ3 and CK1ε, but does not inhibit CK1α .
