Cart
sales@molnova.com
DK419
CAS No. 2102672-22-8
DK419( —— )
Catalog No. M26671 CAS No. 2102672-22-8
DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 164 | In Stock |
|
| 10MG | 259 | In Stock |
|
| 25MG | 428 | In Stock |
|
| 50MG | 591 | In Stock |
|
| 100MG | 798 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameDK419
-
NoteResearch use only, not for human use.
-
Brief DescriptionDK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.
-
DescriptionDK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK.(In Vitro):DK419 inhibited the growth of CRC tumor cells in vitro and had good plasma exposure when dosed orally.(In Vivo):DK419 inhibited the growth of patient derived CRC240 tumor explants in mice dosed orally.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayWnt/Notch/Hedgehog
-
TargetWnt/beta/catenin
-
RecptorLDL| UGT1A1
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2102672-22-8
-
Formula Weight407.7
-
Molecular FormulaC16H8ClF6N3O
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 83.33 mg/mL (204.39 mM)
-
SMILESFC(F)(F)c1nc2cc(Cl)cc(C(=O)Nc3ccc(cc3)C(F)(F)F)c2[nH]1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Ngoc TM, et al. Antioxidative activities of galloyl glucopyranosides from the stem-bark of Juglans mandshurica. Biosci Biotechnol Biochem. 2008 Aug;72(8):2158-63.
molnova catalog
related products
-
Roquinimex
Roquinimex (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha.
-
β-Elemonic Acid
Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the anticancer effects of beta-Elemonic acid are related to the MAPK signaling pathway, ROS activation and glutathione depletion in human A549 lung cancer cells.
-
IWP-2
IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses.
