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CRK12-IN-2
CAS No. 1990479-17-8
CRK12-IN-2( —— )
Catalog No. M35735 CAS No. 1990479-17-8
CRK12-IN-2 is a potent inhibitor of CRK12.CRK12-IN-2 inhibits the parasite, with EC50 values of 3.2 and 0.08 nM for Trypanosoma congolense and Trypanosoma vivax, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 276 | In Stock |
|
| 10MG | 394 | In Stock |
|
| 25MG | 616 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCRK12-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionCRK12-IN-2 is a potent inhibitor of CRK12.CRK12-IN-2 inhibits the parasite, with EC50 values of 3.2 and 0.08 nM for Trypanosoma congolense and Trypanosoma vivax, respectively.
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DescriptionCRK12-IN-2 (compound 2) is an inhibitor of CRK12. CRK12-IN-2 shows potency against Trypanosoma congolense and Trypanosoma vivax with EC50 values of 3.2 and 0.08 nM. CRK12-IN-2 can be used for the research of animal trypanosomiasis.
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In Vitro——
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In VivoCRK12-IN-2 (10 mg/kg; s.c. once daily for 4 days) effectively cures mice with T. congolense- and T. vivax-infection.Animal Model:Mice with T. congolense and T. vivax infection Dosage:10 mg/kg Administration: Subcutaneous injection; 10 mg/kg once daily; for 4 days Result:Fully cured both T. congolense- and T. vivax-infected mice for 4 days at a dose of 10 mg/kg.
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Synonyms——
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PathwayMicrobiology/Virology
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TargetParasite
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RecptorParasite
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Research Area——
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Indication——
Chemical Information
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CAS Number1990479-17-8
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Formula Weight529.67
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Molecular FormulaC23H33F2N5O3S2
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Purity>98% (HPLC)
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Solubility——
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SMILESC(=O)(C=1SC(N[C@@H]2CC[C@@H](NS(CC(C)C)(=O)=O)CC2)=NC1N)C3=C(F)C=C(CN(C)C)C=C3F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Smith A, et al. Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis. J Med Chem. 2022 Apr 14;65(7):5606-5624.?
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