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CQ211

CAS No. 2648986-65-4

CQ211( —— )

Catalog No. M35729 CAS No. 2648986-65-4

CQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM, demonstrating significant proliferation inhibitory activity against various cancer cell lines in vitro.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 179 In Stock
5MG 155 In Stock
10MG 235 In Stock
25MG 377 In Stock
50MG 529 In Stock
100MG 759 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    CQ211
  • Note
    Research use only, not for human use.
  • Brief Description
    CQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM, demonstrating significant proliferation inhibitory activity against various cancer cell lines in vitro.
  • Description
    CQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM. CQ211 exhibits potent proliferation inhibition activity against multiple cancer cell lines.
  • In Vitro
    Western Blot Analysis Cell Line:MKN-1 and HT-29 cells Concentration:0, 0.3, 0.6, 1.2, 2.5, and 5.0 μM Incubation Time:4 h Result:Suppresseed the phosphorylation of mTOR in cancer cells.
  • In Vivo
    Animal Model:Female CB17-SCID mice (6-8 weeks of age) injected wtih MKN-1 cells Dosage:25 mg/kg Administration:Intraperitoneal administration; for 18 consecutive days; once daily Result:Inhibited the tumor progression with tumor growth inhibition (TGI) of 30.9%.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2648986-65-4
  • Formula Weight
    521.49
  • Molecular Formula
    C26H22F3N7O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 12.5 mg/mL (23.97 mM; Ultrasonic (<60°C)
  • SMILES
    O=C1C2=C(C=3C(N1)=CC=C(C3)C=4C=CC(OC)=NC4)N(N=N2)C5=CC(C(F)(F)F)=C(C=C5)N6CCNCC6
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ouyang Y, et al. Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro-4H-[1,2,3]triazolo[4,5-c]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor. J Med Chem. 2022 Jun 9;65(11):7833-7842.?
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