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CQ211
CAS No. 2648986-65-4
CQ211( —— )
Catalog No. M35729 CAS No. 2648986-65-4
CQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM, demonstrating significant proliferation inhibitory activity against various cancer cell lines in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 179 | In Stock |
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| 5MG | 155 | In Stock |
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| 10MG | 235 | In Stock |
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| 25MG | 377 | In Stock |
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| 50MG | 529 | In Stock |
|
| 100MG | 759 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCQ211
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NoteResearch use only, not for human use.
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Brief DescriptionCQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM, demonstrating significant proliferation inhibitory activity against various cancer cell lines in vitro.
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DescriptionCQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM. CQ211 exhibits potent proliferation inhibition activity against multiple cancer cell lines.
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In VitroWestern Blot Analysis Cell Line:MKN-1 and HT-29 cells Concentration:0, 0.3, 0.6, 1.2, 2.5, and 5.0 μM Incubation Time:4 h Result:Suppresseed the phosphorylation of mTOR in cancer cells.
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In VivoAnimal Model:Female CB17-SCID mice (6-8 weeks of age) injected wtih MKN-1 cells Dosage:25 mg/kg Administration:Intraperitoneal administration; for 18 consecutive days; once daily Result:Inhibited the tumor progression with tumor growth inhibition (TGI) of 30.9%.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2648986-65-4
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Formula Weight521.49
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Molecular FormulaC26H22F3N7O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 12.5 mg/mL (23.97 mM; Ultrasonic (<60°C)
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SMILESO=C1C2=C(C=3C(N1)=CC=C(C3)C=4C=CC(OC)=NC4)N(N=N2)C5=CC(C(F)(F)F)=C(C=C5)N6CCNCC6
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ouyang Y, et al. Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro-4H-[1,2,3]triazolo[4,5-c]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor. J Med Chem. 2022 Jun 9;65(11):7833-7842.?
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