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iCRT 14
CAS No. 677331-12-3
iCRT 14( iCRT14 | iCRT-14 | iCRT 14 | Wnt inhibitor )
Catalog No. M18982 CAS No. 677331-12-3
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 50 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 69 | In Stock |
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| 25MG | 117 | In Stock |
|
| 50MG | 184 | In Stock |
|
| 100MG | 346 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameiCRT 14
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NoteResearch use only, not for human use.
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Brief DescriptioniCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
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DescriptioniCRT14 is a potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling in a reporter assay in vitro (IC50 = 40.3 nM). It inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) in quantitative reporter assays of β-catenin/Tcf4 binding (Ki = 53.51 μM).
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In Vitro——
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In Vivo——
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SynonymsiCRT14 | iCRT-14 | iCRT 14 | Wnt inhibitor
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PathwayOthers
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TargetOther Targets
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RecptorWnt
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number677331-12-3
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Formula Weight375.44
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Molecular FormulaC21H17N3O2S
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 29 mg/mL; 77.24 mM
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SMILESO=C4S\C(=C/c2cc(C)n(c1cccnc1)c2C)C(=O)N4c3ccccc3
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Chemical Name5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Gonsalves FC, et al. Proc Natl Acad Sci USA. 2011 Apr 12;108(15):5954-63.
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