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BCP-T.A

CAS No. 2786829-70-5

BCP-T.A( —— )

Catalog No. M35673 CAS No. 2786829-70-5

BCP-T.A is an ferroptosis inducer that acts by binding to GPX4.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    BCP-T.A
  • Note
    Research use only, not for human use.
  • Brief Description
    BCP-T.A is an ferroptosis inducer that acts by binding to GPX4.
  • Description
    BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to GPX4. BCP-T.A is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • In Vitro
    BCP-T.A induces ferroptosis in various cell lines (NCI-H522, T-1080, MDA-MB-468, MDA-MB-231, HeLa, HCT-116, U2OS, WI-38, and MEFS) with IC50 values of 10 nM-367 nM.BCP-T.A (0.5 μM, 3 h) binds to GPX4 and increases lipid peroxides, indicated by cellular thermal shift assay (CETSA).
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Ferroptosis
  • Recptor
    Ferroptosis | GPX
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2786829-70-5
  • Formula Weight
    456.39
  • Molecular Formula
    C23H19Cl2N3OS
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C=1N=C(C#C)SC1)N2CCN(CC2)C(C3=CC=C(Cl)C=C3)C4=CC=C(Cl)C=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Endri Karaj, et al. Design, Synthesis, and Monoamine Oxidase B Selective Inhibitory Activity of N-Arylated Heliamine Analogues. J Med Chem. 2022 Aug 19. ?
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