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BCP-T.A
CAS No. 2786829-70-5
BCP-T.A( —— )
Catalog No. M35673 CAS No. 2786829-70-5
BCP-T.A is an ferroptosis inducer that acts by binding to GPX4.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 135 | In Stock |
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| 10MG | 198 | In Stock |
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| 25MG | 338 | In Stock |
|
| 50MG | 490 | In Stock |
|
| 100MG | 697 | In Stock |
|
| 200MG | 918 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBCP-T.A
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NoteResearch use only, not for human use.
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Brief DescriptionBCP-T.A is an ferroptosis inducer that acts by binding to GPX4.
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DescriptionBCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to GPX4. BCP-T.A is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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In VitroBCP-T.A induces ferroptosis in various cell lines (NCI-H522, T-1080, MDA-MB-468, MDA-MB-231, HeLa, HCT-116, U2OS, WI-38, and MEFS) with IC50 values of 10 nM-367 nM.BCP-T.A (0.5 μM, 3 h) binds to GPX4 and increases lipid peroxides, indicated by cellular thermal shift assay (CETSA).
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetFerroptosis
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RecptorFerroptosis | GPX
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Research Area——
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Indication——
Chemical Information
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CAS Number2786829-70-5
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Formula Weight456.39
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Molecular FormulaC23H19Cl2N3OS
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C=1N=C(C#C)SC1)N2CCN(CC2)C(C3=CC=C(Cl)C=C3)C4=CC=C(Cl)C=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Endri Karaj, et al. Design, Synthesis, and Monoamine Oxidase B Selective Inhibitory Activity of N-Arylated Heliamine Analogues. J Med Chem. 2022 Aug 19. ?
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