Tribendimidine

Research use only, not for human use.

Tribendimidine is a broad-spectrum, orally active anthelmintic and an L-type nicotinic acetylcholine receptor (nAChR) agonist. tribendimidine is highly active against A. lumbricoides and N. americanus.

Tribendimidine is an orally active, broad-spectrum anthelmintic agent, with particularly high activity against A. lumbricoides and N. americanus. Tribendimidine is also an L-type nicotinic acetylcholine receptor (nAChR) agonist.

Tribendimidine (100 μg/mL; 24 h) shows intoxication of C. elegans.Tribendimidine (0-100 μg/mL; 6 days) shows toxicity with an LC50 value (concentration at which half the animals are dead) of 54.4 μg/mL.Tribendimidine (0-200 μg/mL; 64 h)-induced sterility is resisted by trb mutant hermaphrodites, and Levamisole-resistant mutants are resistant to Tribendimidine.

Tribendimidine (75 and 150 mg/kg; p.o.; once) shows inhibition activity against C. sinensis in rats, and shows inhibition against O. viverrini at 400 mg/kg in hamsters.Animal Model:C. sinensis infected Female Wistar rats Dosage:75 mg/kg and 150 mg/kg Administration:Oral administration, once Result:A 99.1% worm burden reduction was achieved at 150 mg/kg, and the worm burden reduction was still significant (68.9%) at 75 mg/kg.

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Cell Cycle/DNA Damage

AChR

AChR

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115103-15-6

452.59

C28H32N6

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (110.48 mM; Ultrasonic; (HCL ，pH≈3); )

CN(C)C(\C)=N\c1ccc(cc1)\N=C\c1ccc(\C=N\c2ccc(cc2)\N=C(/C)N(C)C)cc1

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(-20℃)

With Ice Pack

≥ 2 years