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VU0152099
CAS No. 612514-42-8
VU0152099( VU 0152099 | VU-0152099 )
Catalog No. M27937 CAS No. 612514-42-8
VU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
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| 10MG | 32 | In Stock |
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| 25MG | 65 | In Stock |
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| 50MG | 109 | In Stock |
|
| 100MG | 175 | In Stock |
|
| 200MG | 251 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVU0152099
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NoteResearch use only, not for human use.
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Brief DescriptionVU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM).
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DescriptionVU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM).
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In VitroVU0152099 (30 μM) induces a dose-dependent leftward shift of the acetylcholine (ACh) concentration response curve (CRC) with maximal shifts of 30-fold observed with 30 μM. VU0152099 dose-dependently potentiates the response to an EC20 concentration of ACh with EC50 values of 1.2 μM, and increases the maximal response to ACh to approximately 130%. VU0152099 is a potent positive allosteric modulator that enhance the response of the M4 receptor to the endogenous agonist ACh.
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In VivoVU0152099 (56.6 mg/kg; i.p.; once) reverses Amphetamine-induced hyperlocomotion in rats. Animal Model:Male Sprague-Dawley rats (270-300 g) injected with Amphetamine Dosage:56.6 mg/kg .Administration:i.p.; once Result:Reversed Amphetamine-induced hyperlocomotion in rats.
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SynonymsVU 0152099 | VU-0152099
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PathwayCell Cycle/DNA Damage
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TargetAChR
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RecptorS1P
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Research Area——
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Indication——
Chemical Information
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CAS Number612514-42-8
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Formula Weight355.41
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Molecular FormulaC18H17N3O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 12.5 mg/mL (35.17 mM)
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SMILESCc1cc(C)c2c(N)c(sc2n1)C(=O)NCc1ccc2OCOc2c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Vogt D, et al. Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5354-67.
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